Engineering Polymersome Protocells
نویسندگان
چکیده
منابع مشابه
Molecular engineering of polymersome surface topology.
Biological systems exploit self-assembly to create complex structures whose arrangements are finely controlled from the molecular to mesoscopic level. We report an example of using fully synthetic systems that mimic two levels of self-assembly. We show the formation of vesicles using amphiphilic copolymers whose chemical nature is chosen to control both membrane formation and membrane-confined ...
متن کاملGiant Polymersome Protocells Dock with Virus Particle Mimics via Multivalent Glycan-Lectin Interactions
Despite the low complexity of their components, several simple physical systems, including microspheres, coacervate droplets and phospholipid membrane structures (liposomes), have been suggested as protocell models. These, however, lack key cellular characteristics, such as the ability to replicate or to dock with extracellular species. Here, we report a simple method for the de novo creation o...
متن کاملEngineering Protocells: Prospects for Self-Assembly and Nanoscale Production-Lines
The increasing ease of producing nucleic acids and proteins to specification offers potential for design and fabrication of artificial synthetic "organisms" with a myriad of possible capabilities. The prospects for these synthetic organisms are significant, with potential applications in diverse fields including synthesis of pharmaceuticals, sources of renewable fuel and environmental cleanup. ...
متن کاملReplicator Dynamics in Protocells
Replicator equations have been studied for three decades as a generic dynamical system modelling replication processes. Here we show how they arise naturally in models of self-replicating polymers and discuss some of their basic properties. We then concentrate on a minimal dynamic model of a protocell by coupling replicating polymers with a growing membrane.
متن کاملProtein stabilisation by polymersome entrapment
We report the use of synthetic vesicles formed by amphiphilic block copolymers in water (or polymersomes) to encapsulate myoglobin varying the vesicle size, and protein concentration. We show that confinement within polymersomes leads to a significant improvement in protein stability against thermal denaturation up to 95oC at neutral pH, with little or no evidence of unfolding or reduced enzyma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physical Chemistry Letters
سال: 2011
ISSN: 1948-7185
DOI: 10.1021/jz200640x